Publications by authors named "M E Malla"
Article Synopsis
- Traumatic pneumothorax is a serious condition that needs quick diagnosis and treatment, and lung ultrasound (LUS) is a promising method for early detection by novice physicians.
- The study involved 96 patients with chest injuries, comparing LUS accuracy against standard diagnostic methods like chest X-rays and CT scans, showing LUS had a sensitivity of 100% and specificity of 97.75%.
- The findings suggest that LUS is a practical and effective diagnostic tool for traumatic pneumothorax, making it important for physicians in various healthcare settings to be trained in its use.
Biological monitoring of soil pollution caused by two different zinc species using earthworms.
Environ Sci Pollut Res Int
October 2024
Zinc oxide nanoparticles (ZnO-NPs) are commonly used in both commercial and agricultural sectors. As a result, ZnO-NPs are extensively discharged into soil ecosystems, creating a significant environmental issue. Therefore, it is crucial to assess their influence on the soil ecology to ensure its secure and enduring utilization in the future.
View Article and Find Full Text PDFThe expression of the protein Mesothelin (MSLN) is highly variable in several malignancies, including colorectal cancer (CRC), and high levels are associated with aggressive clinicopathological features and worse patient survival. Colorectal cancer is both a common and deadly cancer; being the third most common in incidence and second most common cause of cancer-related death. While systemic therapy remains the primary therapeutic option for most patients with stage IV (metastatic; m) CRC, their disease eventually becomes treatment refractory, and 85% succumb within 5 years.
View Article and Find Full Text PDFCombination of ionizing radiation and 2-thio-6-azauridine induces cell death in radioresistant triple negative breast cancer cells by downregulating CD151 expression.
Cancer Chemother Pharmacol
November 2024
Background: Triple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer and is frequently resistant to therapy, ultimately resulting in treatment failure. Clinical trials have demonstrated the potential of sensitizing radiation therapy (RT)-resistant TNBC through the combination of chemotherapy and RT. This study sought to explore the potential of CD151 as a therapy response marker in the co-treatment strategy involving ionizing radiation (IR) and the repurposed antiviral drug 2-Thio-6-azauridine (TAU) for sensitizing RT-resistant TNBC (TNBC/RR).
View Article and Find Full Text PDFArticle Synopsis
- - Determining the best treatment plan for rectal cancer is complicated, involving choices between curative or palliative surgery and considering impact on bowel function and quality of life, especially for distal rectal cancer patients.
- - Patients with rectal cancer face a higher risk of pelvic recurrence compared to those with colon cancer, making careful patient selection and a multidisciplinary treatment approach essential for better outcomes.
- - Recent updates to the NCCN Guidelines for Rectal Cancer include new treatment options like endoscopic submucosal dissection for early cases, revisions to the total neoadjuvant therapy strategy, and a nonoperative "watch-and-wait" option for patients who respond well to initial therapy.