Publications by authors named "M E M Dolman"
Article Synopsis
- * A case of a patient with ETV6-MECOM fusion-positive refractory AML used molecular analysis and drug screening to discover a novel combination therapy involving Ruxolitinib and hydroxyurea, which improved disease control and quality of life.
- * This case highlights the effectiveness of high throughput drug screening in guiding treatment decisions for high-risk leukaemia patients and the potential benefit of JAK1/2 inhibitors in palliative care.
Article Synopsis
- * A study tested 125 patient samples against 126 anticancer drugs, finding strong correlations between specific genomic alterations and effective drug responses, indicating potential targeted treatments.
- * The integration of high-throughput screening (HTS) with molecular profiling can enhance precision medicine by identifying effective biomarkers and drug combinations for high-risk pediatric cancer patients.
Background: Pediatric cancer is the leading cause of disease-related death in children and the need for better therapeutic options remains urgent. Due to the limited number of patients, target and drug development for pediatrics is often supplemented by data from studies focused on adult cancers. Recent evidence shows that pediatric cancers possess different vulnerabilities that should be explored independently from adult cancers.
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