Publications by authors named "M E Kreis"
We present, to our knowledge, the first methodological study aimed at enhancing the prognostic power of Cox regression models, widely used in survival analysis, through optimized data selection. Our approach employs a novel two-stage mechanism: by framing the prognostic stratum matching problem intuitively, we select prognostically representative patient observations to create a more balanced training set. This enables the model to assign equal attention to distinct prognostic subgroups.
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- Some studies found that specific gene markers (KRAS or BRAF) combined with other health factors can lead to bad results for people with liver cancer, making surgery not very helpful.
- The research looked at data from over 1,600 patients to see how long they lived after surgery and found many didn’t survive long, especially those with risky KRAS mutations.
- The findings suggest that in some cases, surgery might not be the best option for these patients, similar to those who only got treatment without surgery.
Background: To date, only two studies have compared the outcomes of patients with liver-limited BRAF V600E-mutated colorectal liver metastases (CRLMs) managed with resection versus systemic therapy alone, and these have reported contradictory findings.
Methods: In this observational, international, multicentre study, patients with liver-limited BRAF V600E-mutated CRLMs treated with resection or systemic therapy alone were identified from institutional databases. Patterns of recurrence/progression and overall survival were compared using multivariable analyses of the entire cohort and a propensity score-matched cohort.
Article Synopsis
- Neoadjuvant therapy (NT) is a standard treatment for locally advanced rectal cancer, and endoscopic vacuum therapy (EVT) is used to address anastomotic leakage after rectal surgery.
- A study analyzed 243 patients who underwent rectal resection, finding that 19.3% experienced anastomotic leakage requiring EVT, with 61.7% of these patients receiving NT.
- Results showed no significant differences in EVT duration, healing time, treatment failure rates, or ostomy reversal between patients who received NT and those who didn't, indicating that NT does not negatively impact EVT outcomes.