[Status of the monooxygenase enzyme system in rat and rabbit organs in sugar diabetes and upon insulin administration].

Content of cytochromes P450 and b5, activities of amidopyrine-N-demethylase, alanine- and p-nitrophenol hydroxylases, NADPH-cytochrome c reductase were studied in the liver, kidney, small intestine and lung tissues of rats and rabbits in insulin-dependent hypoglycemia and alloxan diabetes. The diabetes and hypoglycemia caused dissimilar alterations in activity of alanine- and p-nitrophenol hydroxylases, thus indicating their dependence on blood sugar levels. The activity of monooxygenase enzymes studied was altered similarly in rabbit liver and other tissues, while the enzymatic activity was distinctly differentiated in rat tissues.

[Change in the drug-metabolizing function of the liver in patients in the postoperative period in relation to the type of anesthesia].

Anesthesia-dependent changes in pharmaco-metabolic liver function have been studied in patients operated on for cosmetic facial defects. It has been established that the postoperative period in patients subjected intraoperatively to general combined anesthesia and controlled lung ventilation was characterized by inhibited drug metabolism in the liver, which required correction of the drug doses to reduce the risk of side and toxic effects of pharmacotherapy. Patients operated on under local procaine anesthesia had no considerable changes in pharmaco-metabolic liver function in the postoperative period.

[The metabolism of drugs and endogenous substrates in the organs of rabbits following partial hepatectomy and liver ischemia].

The intensity of metabolism of hexenal, amidopyrine, phenacetin, promedol, acetone, hydrocortisone, testosterone and prostaglandin E2 by the isolated microsomes of the liver, kidneys, small intestinal mucosa and lungs was studied polarographically by the rate of oxygen absorption in experiments on 20 male rabbits four days following partial hepatectomy and liver ischemia. It was found that with both models of the liver damage there was observed a decrease of metabolism of amidopyrine, hexenal, phenacetin and an increase of metabolism of hydrocortisone and prostaglandin E2. In the lungs one could observe an increase of metabolism of the studies drugs following hepatectomy and its inhibition in liver ischemia.

[The use of benzonal and saparal in the combined therapy of patients with acute inflammatory processes of the maxillofacial area].

The efficacy of inductors and adaptogens (benzonal and saparal) in combined therapy of patients with acute maxillofacial inflammations was investigated. These agents were conducive to shortening of the treatment periods and prevented complications (chronic osteomyelitis). A sooner recovery of the disordered homeostatic constants of the body (microsomal monoxygenase activities, acetylation processes, nonspecific resistance, leukocytic index of intoxication) was achieved.

[The detoxifying function of the liver following its partial denervation in rats with different autonomic reactivities].

In male rats divided into two groups by their vegetative reactivity ("vagotonics" and "sympathicotonics"), the effect of liver denervation on activity of the monoxygenase enzyme system of the hepatocytes responsible for the hepatic detoxication potential, was studied. The hepatic denervation led to uneven decrease in microsomal monoxygenase enzymes activity in animals with different vegetative reactivity.