Publications by authors named "M E Kolb"
Background: We sought consensus among practising respiratory physicians on the prediction, identification and monitoring of progression in patients with fibrosing interstitial lung disease (ILD) using a modified Delphi process.
Methods: Following a literature review, statements on the prediction, identification and monitoring of progression of ILD were developed by a panel of physicians with specialist expertise. Practising respiratory physicians were sent a survey asking them to indicate their level of agreement with these statements on a binary scale or 7-point Likert scale (- 3 to 3), or to select answers from a list.
Objectives: To evaluate the performance of a custom-made convolutional neural network (CNN) algorithm for fully automated lesion tracking and segmentation, as well as RECIST 1.1 evaluation, in longitudinal computed tomography (CT) studies compared to a manual Response Evaluation Criteria in Solid Tumors (RECIST 1.1) evaluation performed by three radiologists.
View Article and Find Full Text PDFBats provide important ecosystem services for agriculture, such as pest control, a function that is particularly relevant for small-scale farmers. However, climate change is causing a decrease in bat populations. To assess the potential impacts of climate change on insectivorous bats and the implications on small-scale farming of indigenous communities in the Chiapas Highlands in southern Mexico we developed a three-step protocol: (1) projecting distribution shifts of insectivorous bats under climate change scenarios using non-dispersal and limited-full dispersal assumptions, (2) using official information to estimate the average economic value of conducting chemical pest control in crops at a state level, (3) surveying small-scale farmers to estimate the local economic value of pest control and determine how bats are perceived by small-scale farmers.
View Article and Find Full Text PDFArticle Synopsis
- Idiopathic pulmonary fibrosis (IPF) is a severe lung disease marked by excessive scarring, leading to poor respiratory function and a need for new treatment strategies, particularly involving macrophages, the key immune cells in the lungs.
- The study aimed to explore macrophage behavior in lung slices (PCLS), which are real lung tissues cultured in a lab, to better replicate the lung environment compared to isolated cells in vitro.
- Results showed that a polarization cocktail of specific cytokines can induce macrophage markers related to lung fibrosis in PCLS without harming the tissue, demonstrating a promising model for studying macrophage roles in IPF.
Background: Progressive pulmonary fibrosis (PFF) is of substantial interest for novel pharmacotherapy discovery, but little is known about clinical trial eligibility criteria. We evaluated eligibility criteria of PPF randomized controlled trials (RCTs), their representativeness in registry patients, and forced vital capacity (FVC) changes and mortality according to trial eligibility.
Methods: A systematic search was used to identify completed and in-progress phase II and III PPF RCTs.