Publications by authors named "M E Knobloch"
The universe of possible chloro-paraffin (CP) structures is a complex one. Even the world of short-chain CPs (SCCPs) is large, containing thousands of constitutional isomers and stereoisomers. We investigated a technical SCCP mixture (Hordalub 80, Vantage Leuna, m = 56%) and found 33 CP-homologues in this material with carbon- (n) and chlorine-numbers (n) varying from 10 to 13 and 4-12, respectively.
View Article and Find Full Text PDFHigh production rates of chlorinated paraffins (CPs) and their widespread use resulted in a global contamination. Since 2017, short-chain CPs (SCCPs, C-C) are listed as persistent organic pollutants (POPs) in the Stockholm Convention. Technical CP mixtures contain hundreds of homologues and side products such as chlorinated olefins (COs), diolefins (CdiOs) and triolefins (CtriOs).
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- Multiple myeloma (MM) is still an incurable cancer despite available therapies, with T-cell bispecific antibodies (TCBs) targeting BCMA and GPRC5D showing promise but facing issues like resistance and relapse due to antigen loss.
- Forimtamig is a novel GPRC5D-targeting TCB that works more effectively than traditional formats by forming stable immunological connections, leading to better tumor cell destruction and T cell activation in preclinical studies.
- Current research is exploring forimtamig in clinical trials for relapsed and refractory MM patients, both alone and alongside traditional care and new therapies, to enhance treatment outcomes and prevent relapses.
Chlorinated paraffins (CPs) are complex mixtures of polychlorinated -alkanes with multiple carbon- (C-, = 9-30) and chlorine homologues (Cl-, = 3-18). The mass spectrometric analysis of CPs is time-consuming and challenging, especially when interferences between CPs, their transformation products, or from the matrix are numerous. These analytical challenges and the lack of appropriate and accessible data evaluation tools are obstacles to their analysis.
View Article and Find Full Text PDFLipid droplets (LDs) are dynamic lipid storage organelles. They are tightly linked to metabolism and can exert protective functions, making them important players in health and disease. Most LD studies in vivo rely on staining methods, providing only a snapshot.
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