Publications by authors named "M E Holman"
Background: 6.2 million Americans live with heart failure (HF) and are at risk for hospitalization due to hypertensive emergencies. Optimal treatment strategy for acute hypertensive heart failure remains unclear.
View Article and Find Full Text PDFThis case report discusses a rare instance of polymicrobial pericarditis in a man in his early 60s with a history of substance abuse. The patient presented with chest pain and shortness of breath, later diagnosed as pericarditis caused by , and , likely originating from a large adjacent oesophageal ulcer. The condition led to critical illness, requiring pericardiocentesis, antibiotic and antifungal therapy.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how the level of measurable residual disease (MRD) in adults with FLT3-ITD acute myeloid leukemia (AML) affects relapse and mortality rates after allogeneic hematopoietic cell transplant.
- Researchers performed DNA sequencing on blood samples from 537 patients who were in first complete remission prior to transplant, analyzing data up until May 2022.
- Results indicate a significant correlation between residual FLT3-ITD markers and patient outcomes, emphasizing that higher levels of MRD are linked to increased risks of relapse and death after the transplant.
Clostridioides difficile infections (CDIs) are responsible for a significant number of antibiotic-associated diarrheal cases. The standard-of-care antibiotics for C. difficile are limited to fidaxomicin and vancomycin, with the recently obsolete metronidazole recommended if both are unavailable.
View Article and Find Full Text PDF