Global Health Initiatives: International Physician-to-Physician Consultation Programs.

Purpose: The goal of this article is to provide technical and operational blueprints for two successful global telehealth programs.

Methods: The authors designed a physician-to-physician consultation program to provide subspecialty expertise to physicians in war-torn Ukraine. Leveraging secure web applications, telehealth platforms, and image-sharing platforms, the authors repeatedly iterated upon infrastructure and workflows, which in turn facilitated the development of a parallel international program for US Department of State (DOS) employees and families.

Creating an Autonomous Hovercraft for Bathymetric Surveying in Extremely Shallow Water (<1 m).

Coastal shallow water environments (<5 m) are extremely biodiverse and dynamic yet are often mapped too infrequently or at too low resolutions to capture the important processes occurring in these regions. Common forms of coastal surveying can leave gaps in data in the shallow water zone due to optical instrument capabilities and a vessel's ability to navigate in this region. One solution to these issues is an autonomous hovercraft that can fly over land and water and begin surveying at sub-meter water depths, bridging the gap between common optical and acoustic surveying methods.

Underwater noise from submarine turbidity currents.

Noise from turbidity currents flowing down the face of a fjord delta was measured underwater at frequencies from 1 to 1200 kHz. The noise spectra are consistent with sound generation by collisions among sand-sized particles. The spectra from the leading head extend to higher frequencies than those from the trailing body, indicating that collisions were between finer-grained particles in the head and coarser-grained particles in the body.

Preparation of Methyltriazolo[1,4]benzodiazepine via Oxidative Activation of a Thiolactam for the Synthesis of BET Inhibitor Molibresib.

A novel oxidative activation of a thiolactam was developed for the preparation of methyltriazolo[1,4]benzodiazepine in a single step. A sulfenic acid (R-SOH) was proposed as the activated intermediate with the concurrent formation of acetylhydrazone from acethydrazide and cyclocondensation to the triazole. A version of the method with 35% peracetic acid was scaled up to 40 kg as a part of the new route for the synthesis of BET inhibitor molibresib (GSK525762).