Publications by authors named "M E Haines"
A new species of rock skink Liopholis Fitzinger 1843 (Scincidae) is described from the Mann-Musgrave Ranges of north-western South Australia. Liopholis margaretae sensu lato (Storr 1968) is currently known to occur in two disjunct populations: the MacDonnell Ranges bioregion and nearby regions in the Northern Territory, and the Central Ranges bioregion in South Australia. Based on morphological examination of both museum and field specimens, as well as on newly generated molecular data, we show that specimens from these two ranges constitute distinct species.
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- The study presents an optimized workflow for analyzing formalin-fixed, paraffin-embedded (FFPE) patient tissues to uncover molecular insights linked to clinical outcomes, utilizing advanced techniques like Adaptive Focused Acoustics (AFA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS).
- The method allows for the analysis of up to 96 samples, identifying between 8,000-10,000 unique proteins with a high level of quantitative accuracy (<20% median CVs).
- Applied to lung adenocarcinoma FFPE blocks, the workflow demonstrates superior deep proteome coverage and efficiency, significantly contributing to biomarker discovery and proteomic research in archived samples.
Background: Major trauma data in the developed world trends towards increased rates of lower energy mechanism in an older cohort. This study examines how the mechanism of trauma, injury pattern and outcomes differ between a younger and older cohorts in an Irish trauma unit.
Methods: In this retrospective study, all entries to the Trauma Audit and Research Network (TARN) database from Tallaght University Hospital, between January 1st 2016 and 31st December 2021, were interrogated.
Article Synopsis
- * Researchers used advanced LC-MS/MS assays to test whether higher serum myostatin levels correlate with lower insulin sensitivity in 74 overweight/obese adults aged 20-65 without type 2 diabetes.
- * The findings revealed that higher serum myostatin levels were linked to lower insulin sensitivity (Matsuda index) even after accounting for factors like BMI and sex, suggesting myostatin might play a role in the development of insulin resistance.