Publications by authors named "M E Fransen"
The core spliceosome Sm proteins are gaining attention as potential targets for cancer treatment. Here, we evaluate this, with focus on SmD2. A pan-cancer analysis including 26 solid tumor types revealed that the SmD2-encoding gene was overexpressed in almost all cancers.
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- The denial of death in society hinders individuals from fully experiencing life, prompting the Lancet Commission to advocate for a future where death is acknowledged and openly discussed.* -
- An art installation aimed to help visitors confront their mortality through guided meditation, and its effectiveness was compared to traditional death reflection methods.* -
- Results showed the art installation resulted in higher emotional responses and a sustained increase in life appreciation, illustrating the potential of art to enhance our relationship with death and promote a deeper value of life.*
This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state-of-the-art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy, and functional characterization of mouse and human dendritic cells (DC) from lymphoid organs, and various nonlymphoid tissues. Within this article, detailed protocols are presented that allow for the generation of single-cell suspensions from human nonlymphoid tissues including lung, skin, gingiva, intestine as well as from tumors and tumor-draining lymph nodes with a subsequent analysis of dendritic cells by flow cytometry. Further, prepared single-cell suspensions can be subjected to other applications including cellular enrichment procedures, RNA sequencing, functional assays, etc.
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- * Higher catalase (CAT) activity was found in malignant cell lines compared to benign ones, contradicting previous findings, and reducing CAT expression through RNA interference led to increased proliferation in certain cancer cell lines.
- * Activation of the androgen receptor (AR) increases expression of enzymes that produce harmful oxidation in peroxisomes while decreasing CAT levels, suggesting that AR activity in PCa influences redox balance to support cancer cell survival and growth.