Publications by authors named "M E Fogel"
Background: Deterioration of right ventricular (RV) function in repaired tetralogy of Fallot (rToF) is poorly understood. Cardiovascular magnetic resonance (CMR) is used for monitoring, but its analysis is user-dependent and time-consuming. We sought to automate the analysis of CMR using machine learning, and to identify imaging traits associated with adverse RV remodeling in the natural history of rToF.
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- Patients with congenital heart disease, particularly those who have undergone the Fontan procedure for single ventricle issues, face a high risk of sudden cardiac events (SCE) and early mortality, highlighting the importance of identifying risk factors.
- In a study involving 3,132 Fontan patients, 3.5% experienced SCE over an average follow-up of 4 years, with 36% of those cases resulting in death.
- Key risk factors for SCE included higher NYHA functional class, history of protein-losing enteropathy or plastic bronchitis, large end-diastolic volume index, and reduced ejection fraction, all of which can help in predicting and preventing such events.
Article Synopsis
- - The study utilized data from the FORCE registry to analyze cardiac magnetic resonance (CMR) metrics in healthier Fontan patients, aiming to create Fontan-specific z-scores that consider different ventricular morphologies.
- - The "healthier" cohort consisted of 885 patients, primarily children, who were assessed for ventricular size and function against those with adverse outcomes, revealing that those with left ventricle morphology had better metrics.
- - Comparisons showed adults had lower blood flow in the ascending aorta than children, and patients with adverse outcomes tended to have higher heart volumes and mass, which suggests a link between ventricular morphology and patient prognosis post-Fontan surgery.
Article Synopsis
- Current methods to predict sudden cardiac death (SCD) in children with hypertrophic cardiomyopathy (HCM) are insufficient, although late gadolinium enhancement (LGE) in CMR imaging has shown a link to SCD in adults.
- This study aimed to assess the significance of LGE in HCM patients under 21 years, utilizing data from various international centers between 2015 and 2022.
- Results indicated that 32.9% of the 700 patients had LGE, and those with LGE were more likely to experience SCD or related events, emphasizing the potential role of LGE in clinical assessments for younger patients with HCM.
Article Synopsis
- Fontan patients generally have reduced exercise capacity, but some are categorized as high-performing Fontan (HPF) patients with excellent exercise capacity.
- The study aimed to develop a tool to predict peak oxygen uptake for Fontan patients, explore clinical factors linked to HPF status, and analyze long-term outcomes for these patients.
- Findings indicated that HPF patients had better left ventricular morphology, were less likely to have certain complications, and had a significantly lower risk of death or needing a heart transplant compared to those with lower exercise capacity.