Patient characteristics in relation to opioid exposure in a chronic non-cancer pain population.

Objectives: The efficacy of long-term opioid therapy (LTOT) in treating patients with chronic non-cancer pain (CnCP) is questionable, and the potential risks of adverse effects are well established. The aims were as follows: (1) compare characteristics in patients exposed to LTOT vs non-exposed. (2) Regarding opioid-exposed patients, describe characteristics of patients with risk factors for opioid use disorder or overdose in relation to opioid dosage.

Use of polymerase chain reaction to characterize the etiology of culture-negative empyema and parapneumonic effusion among Alaska Native children - 2018-2023.

We used polymerase chain reaction (PCR) to identify bacterial infections in culture-negative pleural fluid specimens from Alaska Native children hospitalized with empyema. PCR identified ≥1 organism in 11 (79%) of 14 specimens. Streptococcus pneumoniae serotype 3 was detected in six specimens; all six participants had received 13-valent pneumococcal conjugate vaccine.

Human cold pain: a randomized crossover trial.

The mechanism causing cold pain in humans is unresolved. Animal data suggest a nonredundant contribution to cold pain for transient receptor potential channels TRPM8 and TRPA1 for detection and voltage-gated sodium channels NaV1.7 and NaV1.

Food Authentication Goes Green: Method Optimization for Origin Discrimination of Apples Using Apple Juice and ICP-MS.

Apples are among the most important fruits worldwide and the most consumed fruit in Germany. Due to higher energy and personnel costs, domestic apples are more expensive and thus offer an incentive for mixing with foreign goods. Moreover, imported apples have a higher carbon footprint, which is an obstacle regarding sales in times of climate change.