HLA antigens in multiple sclerosis in coloured South Africans.

HLA-A and HLA-B antigens were determined in 24 Coloured patients with multiple sclerosis (MS) and HLA-DR antigens in 16 of these patients. There was a trend for an increased frequency of HLA-DR2 in the MS group (0.25 greater than P greater than 0.

Measles antibodies and histocompatibility types in multiple sclerosis.

Measles antibody titres and HLA antigens were determined in 71 White and 11 Coloured multiple sclerosis (MS) patients and 71 White and 11 Coloured age and sex-matched controls. Measles antibody titres were determined by the hemagglutination inhibition test and HLA antigens were determined serologically by a micro-lymphocytotoxicity test. Measles antibody titres were significantly higher in MS than in control cases and this was true for both female and male patients.

Histocompatibility types and measles antibodies in multiple sclerosis.

The relationship between HLA antigens and measles antibody titers was investigated in 105 multiple sclerosis (MS) patients. HLA antigens were determined serologically by a micro-lymphocytotoxicity test and measles antibody titers were determined by the hemagglutination inhibition test. There was an increased frequency of HLA-B7 and HLA-Bw35 antigens and a decreased frequency of HLA-A2, HLA-B12, and HLA-Bw40 antigens in MS.

Lipid composition of myelin in multiple sclerosis.

Myelin was isolated from histologically normal white matter and plaques from MS patients and from white matter of neurologically normal controls. No difference was found in the total lipid content. There were no detectable deficits in MS myelin of phosphoglycerides, plasmalogens or sphingolipids.