Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue.

With age, people tend to accumulate body fat and reduce energy expenditure . Brown (BAT) and beige adipose tissue dissipate heat and increase energy expenditure via the activity of the uncoupling protein UCP1 and other thermogenic futile cycles . The activity of brown and beige depots inversely correlates with BMI and age , suggesting that promoting thermogenesis may be an effective approach for combating age-related metabolic disease .

Generation and characterization of Ccdc28b mutant mice links the Bardet-Biedl associated gene with mild social behavioral phenotypes.

CCDC28B (coiled-coil domain-containing protein 28B) was identified as a modifier in the ciliopathy Bardet-Biedl syndrome (BBS). Our previous work in cells and zebrafish showed that CCDC28B plays a role regulating cilia length in a mechanism that is not completely understood. Here we report the generation of a Ccdc28b mutant mouse using CRISPR/Cas9 (Ccdc28b mut).

A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress.

Cells have the ability to sense, respond and adapt to environmental fluctuations. Stress causes a massive reorganization of the transcriptional program. Many examples of histone post-translational modifications (PTMs) have been associated with transcriptional activation or repression under steady-state growth conditions.

[Evidence of the political use of medical science in a Brazilian newspaper article on the Chilean president José Manuel Balmaceda in 1891].

In the midst of the Civil War in Chile in 1891, the Brazilian newspaper Diário de Campinas published an article entitled "Balmaceda," by Joaquim Nogueira de Sá Itagiba, which analyzes the delirium of Chilean politician José Manuel Balmaceda, president of the Republic from 1886 to 1891 in order to explain his behavior, which it defines as characteristic of a dictator and a tyrant. The article makes liberal use of various psychiatric theories that sought to identify the criminal subject in response to ideals of social normalization. The article was part of the book La prensa extranjera y la dictadura chilena, by Alberto Fagalde, published in 1891, in Chile.

Association of mutation and atypical diabetes in a Uruguayan population.

Aim: To investigate if mutations in are associated with "atypical diabetes" in the Uruguayan population.

Methods: Healthy, nondiabetic controls ( = 133) and patients with type 2 diabetes ( = 177) were selected from among the presenting population at level-3 referral healthcare centers in Uruguay. Patients with type 2 diabetes were subgrouped according to "atypical diabetes" ( = 92) and "classical diabetes" ( = 85).