Publications by authors named "M E Ewoud Baarsma"
Article Synopsis
- * Potential factors contributing to these symptoms may include immune system issues, metabolic changes, pain sensitization, and cognitive-behavioral aspects, but research is ongoing to clarify these links.
- * The authors advocate for a comprehensive classification system for all patients experiencing lingering symptoms after Lyme disease, to improve research and patient care, despite the unclear biological causes.
Objectives: To describe the course of symptoms reported by patients with symptoms attributed to Lyme borreliosis (LB) without being subsequently diagnosed with LB.
Methods: We performed a prospective cohort study with patients presenting at the outpatient clinic of two clinical LB centres. The primary outcome was the prevalence of persistent symptoms, which were defined as clinically relevant fatigue (CIS, subscale fatigue), pain (SF-36, subscale bodily pain), and cognitive impairment (CFQ) for ≥ 6 months and onset < 6 months over the first year of follow-up.
Background: Patients treated for Lyme borreliosis (LB) frequently report persistent symptoms. Little is known about risk factors and etiology.
Methods: In a prospective observational cohort study with a follow-up of one year, we assessed a range of microbiological, immunological, genetic, clinical, functional, epidemiological, psychosocial and cognitive-behavioral variables as determinants of persistent symptoms after treatment for LB.
Objective: To investigate the typing skills of healthcare professionals.
Design: Cross sectional study.
Setting: Two large tertiary medical centres in Amsterdam, the Netherlands.
Article Synopsis
- Monocytes can be 'trained' or 'tolerized' by specific stimuli, leading to altered immune responses, and changes in glucose metabolism are key to this process.
- Exposure to Borrelia burgdorferi reduces cytokine production in monocytes and lowers glycolysis levels, indicating long-term immune response changes.
- A gene called MFAP3L was identified as influencing lactate production post-B. burgdorferi exposure, with validation showing its role in cytokine production and the involvement of platelets and certain platelet-derived factors in this process.