Publications by authors named "M E Erro"
Article Synopsis
- Mutations in the tau gene can cause a type of brain disease called frontotemporal dementia and parkinsonism, leading to changes in behavior and thinking.
- The study focused on two specific mutations, P301L and P301T, found in different people, revealing unique structures of tau proteins in their brains.
- The researchers suggest that these mutations create special kinds of tau-related brain diseases that should be treated differently in research studies about similar conditions.
Background: Epidemiological studies on multisystem atrophy (MSA) are scarce. Our aim has been to analyse 10-year incidence, point prevalence, survival, and the time to diagnosis of MSA in Navarre, a northern Spanish region.
Methods: This is a population-based observational retrospective study, from 2012 to 2021, which covered the population of Navarre (followed until 31 December 2021).
Ageing-related tau astrogliopathy severely affecting the substantia nigra.
Neuropathol Appl Neurobiol
August 2024
Aims: Astrocytic tau pathology is a major feature of tauopathies and ageing-related tau astrogliopathy (ARTAG). The substantia nigra (SN) is one of the important degenerative areas in tauopathies with parkinsonism. Nigral tau pathology is usually reported as neuronal predominant with less prominent astrocytic involvement.
View Article and Find Full Text PDFNon-cystic fibrosis bronchiectasis, a condition that remains relatively underrecognized, has garnered increasing research focus in recent years. This scientific interest has catalyzed advancements in diagnostic methodologies, enabling comprehensive clinical and molecular profiling. Such progress facilitates the development of personalized treatment strategies, marking a significant step toward precision medicine for these patients.
View Article and Find Full Text PDFIntroduction: Trough blood levels (C) of tacrolimus are used to adjust drug dosage, but they do not consistently correlate with clinical outcomes. Measurement of residual gene expression of nuclear factor of activated T cell (NFAT)-regulated genes (NFAT-RGE) has been proposed as a pharmacodynamic biomarker to assess the degree of immunosuppression in certain solid organ transplantations, but little is known regarding lung transplant recipients (LTR). Our primary objective is to correlate tacrolimus blood levels with NFAT-RGE.
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