Publications by authors named "M E Epstein"
Differential co-expression analysis (DCA) aims to identify genes in a pathway whose shared expression depends on a risk factor. While DCA provides insights into the biological activity of diseases, existing methods are limited to categorical risk factors and/or suffer from bias due to batch and variance-specific effects. We propose a new framework, Kernel-based Differential Co-expression Analysis (KDCA), that harnesses correlation patterns between genes in a pathway to detect differential co-expression arising from general (i.
View Article and Find Full Text PDFObjective: Patients with chronic idiopathic intracranial hypertension (IIH) commonly experience a high level of disability and low satisfaction with medical treatment. We aim to evaluate long-term functional improvement and patient satisfaction in IIH patients with similar symptoms by comparing venous sinus stenting (VSS) to standard medical therapy.
Methods: We conducted a cross-sectional questionnaire study of 111 IIH patients, comparing 37 adult female patients who underwent venous sinus stenting with 74 patients treated medically.
Article Synopsis
- The research highlights that the prevalence of electronic nicotine delivery systems (ENDS) among young adults matches that of traditional cigarettes, indicating a need for tailored prevention strategies that address specific risk and protective factors (RPFs) for each.
- Using data from the Community Youth Development Study involving over 4,000 participants, the study explores how general protective factors and substance-specific RPFs influence young adult use of both cigarettes and ENDS from early adolescence to young adulthood.
- Findings reveal that while general protective factors can indirectly affect young adult nicotine use, targeted interventions focusing on cigarette-specific beliefs and peer substance use are necessary for effective prevention of both cigarette and ENDS use.
Genetically modified strain MXY0541 was developed to produce soy leghemoglobin by introducing the coding sequence encoding leghemoglobin from soybean (). The molecular characterisation data and bioinformatic analyses do not raise any safety concerns. The safety of soy leghemoglobin as a food additive has already been assessed by the EFSA FAF Panel (EFSA-Q-2022-00031).
View Article and Find Full Text PDFFraudulent participation is defined in the following as participation in research by individuals who, for one reason or another, intentionally provide false responses. Qualitative studies are at an increased risk of fraudulent participation when online recruitment and participation are used, and monetary incentives offered. Fraudulent participation threatens data quality and subsequent evidence-based practice, yet validated guidance on how to tackle it is lacking.
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