Publications by authors named "M E Emery"
Background: VY-TAU01 is a recombinant humanized IgG4 monoclonal antibody (mAb) directed against pathological tau for the treatment of patients with mild dementia or mild cognitive impairment due to Alzheimer's disease (AD). Both VY-TAU01 and its parental mouse IgG1 mAb Ab-01 target an epitope in the C-terminus of tau, bind pathological tau with high affinity and selectivity over wild-type tau, block paired helical filament seed-induced tau aggregates in vitro, and selectively stain tau tangles in AD and P301S mouse (C57/B6J-Tg[Thy1-MAPT*P301S]2541Godt) brain. Ab-01 robustly inhibits seeding and propagation of pathological tau in a P301S mouse seeding model.
View Article and Find Full Text PDFSouthern greater gliders (Petauroides volans) are endangered Australian marsupials for which there is little health data currently available. Chlamydia pecorum is the only reported pathogen of greater gliders and infects a broad range of hosts, including other marsupials, ruminants, swine and birds. Conjunctival and cloacal swabs collected from thirty-two southern greater gliders across southeastern New South Wales, Australia were screened for Chlamydia spp.
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- Cnidarians, like jellyfish, often have a mutualistic relationship with photosynthetic dinoflagellates, which helps them gain nutrients but may weaken their immune response.
- Research focused on upside-down jellyfish revealed that symbiotic polyps had lower survival rates when exposed to pathogens compared to those without symbionts.
- Gene studies suggest that the immune responses of symbiotic polyps were more damaging, as they showed higher inflammation and stress levels, indicating a trade-off between nutrition from symbionts and their ability to defend against diseases.
Melanin is an essential product that plays an important role in innate immunity in a variety of organisms across the animal kingdom. Melanin synthesis is performed by many organisms using the tyrosine metabolism pathway, a general pathway that utilizes a type-three copper oxidase protein, called PO-candidates (phenoloxidase candidates). While melanin synthesis is well-characterized in organisms like arthropods and humans, it is not as well-understood in non-model organisms such as cnidarians.
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- The study focused on translating and validating various compassion measurement scales from English to French to enhance research on self-compassion and compassion for others in French-speaking populations.
- A group of 384 French-speaking participants completed these translated measures along with assessments for mental health and well-being.
- Results indicated that the translated measures have good reliability and validity, confirming that they can effectively measure the constructs of compassion as intended.