Publications by authors named "M E E Kretzschmar"
Perioperative management of patients with mediastinal mass syndrome.
Curr Opin Anaesthesiol
December 2024
Purpose Of The Review: The mediastinal mass syndrome (MMS) can occur after induction of anesthesia, intraoperatively or even days after the surgical procedure. The focus of this review is on the management of pediatric and adult patients with a significant mediastinal mass.
Recent Findings: The age distribution of patients with mediastinal lesions suggests a bimodal shape, with an increased incidence among children under 10 years old and adults aged 60-70 years old.
Evaluating diagnostic test accuracy during epidemics is difficult due to an urgent need for test availability, changing disease prevalence and pathogen characteristics, and constantly evolving testing aims and applications. Based on lessons learned during the SARS-CoV-2 pandemic, we introduce a framework for rapid diagnostic test development, evaluation, and validation during outbreaks of emerging infections. The framework is based on the feedback loop between test accuracy evaluation, modelling studies for public health decision-making, and impact of public health interventions.
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- There is a need for effective methods to integrate deuterium into carbon compounds, especially in later stages of synthesis.
- A new synthetic approach for hydrogen isotope exchange (HIE) has been developed using hexafluorophosphate (PF) and deuterated hexafluoroisopropanol (HFIP-d) under mild, ambient conditions.
- This method achieves high yields in deuterating a variety of aromatic compounds and relies on the activation of the P-F bond by HFIP-d through H-bonding, facilitating the formation of deuterated molecules that could be useful in various chemical applications, including pharmaceuticals.
Article Synopsis
- To effectively understand how infectious diseases spread, we need to include human behavior in our models, as current research lacks a cohesive integration of these two aspects.
- The paper presents a new framework that connects infectious disease dynamics with behavior dynamics through four distinct update functions, but highlights a diversity in their application and a lack of model comparisons, making it hard for researchers to create tailored models.
- The authors suggest using 'influence-response functions' to address disagreements about human behavior assumptions in models, and emphasize the importance of social science methods to enhance future research on the interplay between disease and behavior.
Background: Contact tracing (CT) is a key intervention to contain outbreaks of communicable diseases. During large-scale outbreaks, public health services may lack the resources required to perform CT effectively. One way of mitigating this issue is to shift some of the tasks in CT normally performed by public health services to cases and their contacts, supported by digital tools.
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