Outcomes in people with HIV who resume or switch to bictegravir/emtricitabine/tenofovir alafenamide following a treatment interruption.

Objective: Treatment adherence remains critical in maintaining HIV RNA suppression on antiretroviral therapy. High genetic barrier regimens constructed with three long half-life agents may prevent resistance emergence and can be potentially started or restarted after antiretroviral treatment interruption (TI).

Methods: Data from the TRIO US HIV cohort were used to identify adult people with HIV initiating a new ART regimen from January 2021 - November 2023 and describe prevalence of TIs (defined as ≥90 days without dispensed ART).

Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience.

A significant challenge in multi-omic geroscience research is the collection of high quality, fit-for-purpose biospecimens from a diverse and well-characterized study population with sufficient sample size to detect age-related changes in physiological biomarkers. The Dog Aging Project designed the precision cohort to study the mechanisms underlying age-related change in the metabolome, microbiome, and epigenome in companion dogs, an emerging model system for translational geroscience research. One thousand dog-owner pairs were recruited into cohort strata based on life stage, sex, size, and geography.

The risk of complications after hip fracture.

Aims: The risk of mortality after a hip fracture has been extensively investigated, but there is little high-quality information available dealing with the overall risk of complications. The aim of this study was to report the risk of complications in the first 120 days after a hip fracture.

Methods: This was a multicentre, prospective cohort study of patients aged > 60 years with a hip fracture, involving 77 hospitals in England, Wales, and Northern Ireland, between January 2015 and 2022.

How does removing menthol tobacco product displays at point-of-sale affect adolescents' cigarette smoking intentions? The mediating effects of social norms.

This study investigates the psychological mechanisms through which a removal of mentholated tobacco products from retail stores affects future smoking intentions among youth. Descriptive norms and injunctive norms were examined as candidate mediators. The study was conducted in the RAND StoreLab (RSL), a life-sized replica of a convenience store developed to evaluate how changing point-of-sale (POS) tobacco advertising influences tobacco use outcomes during simulated shopping experiences.