Publications by authors named "M E Dolle"
Article Synopsis
- Immune function declines with age, making it difficult to identify individuals at risk for immune-related issues, especially those with reactivated latent viral infections.
- The study focused on detecting certain human herpes viruses in urine as a potential way to identify immune-compromised individuals, particularly using T cell receptor excision circle (TREC) data as an indicator.
- While no clear one-to-one correlation was found between TREC values and individual viruses, a significant link was observed for males; specifically, low TREC values correlated with the detection of three or more different herpes viruses, suggesting declining immune function.
Skin autofluorescence (SAF), reflecting advanced glycation end-products' accumulation in tissue, has been proposed as a non-invasive aging biomarker. Yet, SAF has not been compared to well-established blood-based aging biomarkers such as MetaboHealth in association with frailty. Furthermore, no previous study determined the longitudinal association of SAF with frailty.
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- The study focused on the relationship between Torquetenovirus (TTV) levels, inflammation markers, and the risk of Ischemic Heart Disease (IHD) in older adults, revealing limited research on this topic.
- Findings from 900 non-IHD participants and 86 IHD individuals indicated that elevated TTV viremia was a significant predictor of IHD risk, particularly in males and in conjunction with other health factors like diabetes and smoking.
- The research suggests that high TTV levels are linked to increased inflammation and may contribute to IHD risk through mechanisms related to aging and immune response deterioration.
Background: Working during the night interferes with the timing of normal daily activities and is associated with an increased risk of chronic diseases. Under controlled experimental conditions, interventions focusing on sleep and nutrition can mitigate the short-term adverse effects of shift work. However, it is unclear how these results translate to real-life, how they can be targeted to individual conditions, and how they relate to long-term health.
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- - The study investigates the role of oxidized LDL particles (LDLox) in assessing cardiometabolic risk, focusing on their relationship with other biomarkers and risk factors using data from 1089 participants aged 40-75.
- - Researchers performed correlation analyses and developed machine learning models to predict risks associated with high blood pressure and obesity, achieving promising validation scores that highlighted the significance of LDLox.
- - The findings provide new insights into how LDL oxidation may interact with aging markers to influence cardiometabolic health, suggesting that further research with larger groups could enhance clinical assessment tools.