Publications by authors named "M E Daoudaki"
Detailed characterization of B cells in dialysis patients who are candidates for kidney transplant is still lacking, with little information on how dialysis duration and modality impact B cell subsets. Cluster analysis of flow cytometry determined the frequencies and absolute numbers of B-cell subsets and divided the cohort of 78 candidates into two distinct clusters, one with shorter and one with longer dialysis duration. The immune profiles of the clusters differed depending on whether frequencies or absolute counts were considered.
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- - The study aimed to assess changes in immune cell counts in kidney transplant recipients over a year and how these changes relate to various clinical factors.
- - Using flow cytometry on 112 patients, researchers found most T cell subsets increase post-transplant, with variations influenced by recipient age, donor type, and dialysis method.
- - Key findings indicate that younger recipients and better graft function lead to higher T cell counts, while living donor kidneys and certain dialysis types positively affect immune recovery.
Article Synopsis
- B and T regulatory cells (Bregs and Tregs) play a crucial role in kidney transplantation, and this study aims to track their changes in frequency and numbers before and after transplant.
- Researchers used flow cytometry to analyze cells from 50 kidney recipients without rejection, assessing renal function through estimated glomerular filtration rate (eGFR).
- Findings indicate that at six months post-transplant, Tregs, tBregs, and plasmablasts decreased in frequency, whereas mBregs remained stable; notably, better graft function correlates positively with tBregs and plasmablasts, especially when eGFR is above 60.
Background: B cells have a significant role in transplantation. We examined the distribution of memory subpopulations (MBCs) and naïve B cell (NBCs) phenotypes in patients soon after kidney transplantation. Unsupervised machine learning cluster analysis is used to determine the association between the cellular phenotypes and renal function.
View Article and Find Full Text PDFIntroduction: The importance of preoperative donor/recipient colonization or donor infection by extensively drug-resistant Gram-negative bacteria (XDR-GNB) and its relation to serious post-transplantation infection pathogenicity in liver transplantation (LT) patients has not been clarified.
Aim: Prevention of postoperative infection due to XDR-GNB with the appropriate perioperative chemoprophylaxis or treatment based on preoperative donor/recipient surveillance cultures in LT patients, as well as their outcome.
Materials And Method: Twenty-six patients (20 male, 6 female) were studied (average preoperative Model for End-Stage Liver Disease score ≈15, range: 8-29) from January 2017 to January 2018.