Publications by authors named "M E Cooley"
Article Synopsis
- This study examined how two levels of low-intensity vibration training (0.6 g and 1.0 g) affected muscle and bone recovery in mice after a muscle injury known as volumetric muscle loss (VML).
- Mice were divided into groups receiving either no treatment or varying levels of vibration training for 15 minutes a day over 8 weeks post-injury.
- Results showed that bone structure improved with vibration training, particularly at the 1.0 g level, while muscle function showed less significant enhancement, suggesting that vibration training may be more beneficial for bone recovery than for muscle after VML.
Article Synopsis
- The study investigates challenges in delivering nanoparticle-based drugs to tumors, focusing on the inconsistent success of the enhanced permeability and retention (EPR) effect.
- It introduces a technique using multiparametric dynamic contrast-enhanced ultrasound (CEUS) with nanoscale contrast agents to noninvasively analyze tumor microenvironment features and predict the distribution and effectiveness of doxorubicin-laden liposomes.
- Results indicate that CEUS parameters, like area under the curve and decorrelation time, can accurately differentiate between tumors with varying vascular permeability, potentially serving as biomarkers for treatment responsiveness to nanoparticle therapies.
Article Synopsis
- This systematic review and meta-analysis evaluates the effectiveness of UroVysion FISH testing in detecting pancreaticobiliary malignancy by analyzing various definitions of a positive result from different studies.
- The review included data from 18 studies with a total of 2,516 FISH specimens, identifying 1,133 cases (45.0%) of malignancy, while reporting an overall sensitivity of 57.6% and specificity of 87.8% across studied definitions.
- Results indicated that using polysomy alone as a positive threshold provided high specificity (96.2%) but lower sensitivity (49.4%), whereas combining polysomy with tetrasomy/trisomy improved sensitivity to 64.3% but reduced specificity
Nanobubble Contrast Enhanced Ultrasound Imaging: A Review.
Wiley Interdiscip Rev Nanomed Nanobiotechnol
November 2024
Contrast-enhanced ultrasound is currently used worldwide with clinical indications in cardiology and radiology, and it continues to evolve and develop through innovative technological advancements. Clinically utilized contrast agents for ultrasound consist of hydrophobic gas microbubbles stabilized with a biocompatible shell. These agents are used commonly in echocardiography, with emerging applications in cancer diagnosis and therapy.
View Article and Find Full Text PDFObjective: Deaf and hard of hearing (DHH) women experience higher rates of reproductive healthcare barriers and adverse birth outcomes compared to their hearing peers. This study explores the pregnancy experiences of DHH women who do not sign to better understand their barriers and facilitators to optimal perinatal health care.
Design: Qualitative study using thematic analysis.