Publications by authors named "M E Buyukokuroglu"
Propranolol is the treatment of choice for infantile hemangioma. We investigated the effects of long-term propranolol use in early infancy on learning and memory later in life in mice. At three weeks of age, mice were randomly divided into six experimental groups.
View Article and Find Full Text PDFObjective: Hepatotoxicity is one of the major side effects of methotrexate and limits its use. In this study, we investigated the hepatoprotective effect of silibinin and the role of oxidative stress markers and cytokines on high-dose methotrexate-induced hepatotoxicity in rats.
Materials And Methods: In this study, rats were randomly divided into 5 groups (n=7).
Effects of mirabegron on depression, anxiety, learning and memory in mice.
An Acad Bras Cienc
December 2021
Mirabegron is the first b3-adrenoceptor agonist to enter clinical practice and has been approved for the treatment of symptoms of OAB. The aim of this study is to investigate whether the mirabegron has an effect on depression, anxiety, learning, and memory. We investigated the effects of mirabegron on depression, anxiety, learning and memory by using forced swimming test, elevated plus maze test, passive avoidance and Morris water maze in mice.
View Article and Find Full Text PDFProtective effects of dantrolene and methylprednisolone against spinal cord injury-induced early oxidative damage in rabbit bladder: A comparative experimental study.
Adv Clin Exp Med
December 2019
Background: Spinal cord injury (SCI) may cause dysfunction in the bladder and many distal organs due to systemic inflammatory response and oxidative stress-related injury.
Objectives: We investigated the preventive effects of dantrolene (DNT) and methylprednisolone (MP) on stress-induced tissue damage in rabbit bladder with SCI.
Material And Methods: A total of 35 rabbits were included in this study and they were divided into 5 groups: group 1 - control, group 2 - SCI only, group 3 - SCI and DNT, group 4 - SCI and MP, and group 5 - SCI and DNT+MP.
Article Synopsis
- - Traumatic spinal cord injury (SCI) leads to serious complications with no effective treatment for complete recovery of motor functions, prompting research into the potential benefits of dantrolene (DNT).
- - A study on 38 rabbits revealed that DNT improved motor function and reduced cell death when administered at different time points post-SCI, with the best outcomes observed shortly after the injury.
- - Findings indicate a significant difference in neural transmission between healthy controls and the SCI group, suggesting a need for further research on electophysiological effects that could help develop treatments for SCI.