Publications by authors named "M E Bodini"
Article Synopsis
- The study investigates the diversity of Meningococcal serogroup B (MenB) strains in Argentina and assesses vaccine coverage using genetic tools like gMATS and human serum bactericidal antibodies (hSBA).
- Researchers analyzed 284 MenB isolates, identifying that the four main clonal complexes represented over 81% of the samples, with varying antigen profiles for vaccine candidates.
- Results showed that the 4CMenB vaccine could potentially cover approximately 61.3% of strains based on gMATS predictions and 78.4% based on hSBA assay, highlighting the need for ongoing genomic monitoring of MenB in Argentina.
Article Synopsis
- Whole genome sequencing aids in classifying bacterial strains, allowing for a more comprehensive analysis using machine learning (ML) models.
- A "bag-of-words" approach was developed to tokenize entire genomes, with SentencePiece being the most effective for encoding.
- The ML model achieved high accuracy in classifying bacterial genotypes and phenotypes, and gene knockouts validated the model's predictions against existing biological knowledge.
Unlabelled: Risk and outcome of acute promyelocytic leukemia (APL) are particularly worsened in obese-overweight individuals, but the underlying molecular mechanism is unknown. In established mouse APL models (Ctsg-PML::RARA), we confirmed that obesity induced by high-fat diet (HFD) enhances leukemogenesis by increasing penetrance and shortening latency, providing an ideal model to investigate obesity-induced molecular events in the preleukemic phase. Surprisingly, despite increasing DNA damage in hematopoietic stem cells (HSC), HFD only minimally increased mutational load, with no relevant impact on known cancer-driving genes.
View Article and Find Full Text PDFA maternal vaccine to protect neonates against Group B Streptococcus invasive infection is an unmet medical need. Such a vaccine should ideally be offered during the third trimester of pregnancy and induce strong immune responses after a single dose to maximize the time for placental transfer of protective antibodies. A key target antigen is the capsular polysaccharide, an anti-phagocytic virulence factor that elicits protective antibodies when conjugated to carrier proteins.
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