Publications by authors named "M E Berselli"
Article Synopsis
- Recent advancements in genomics for diagnosing rare diseases focus on "N-of-1" analyses, allowing for tailored studies on individual patients with ultra-rare conditions.
- The Undiagnosed Diseases Network (UDN) enables collaborative research across various U.S. clinical and research centers, which enhances the ability to analyze whole genome sequencing data from multiple patients simultaneously.
- Introducing a new software package, RaMeDiES, the team provides tools for automated comparisons of genomic data, leading to novel disease associations and improving overall understanding of genetic links to these rare diseases.
Article Synopsis
- Interest in metastatic gastric cancer is rising, with the META-GASTRO registry aiming to gather clinical data on oligometastatic patients to guide multimodal treatment, including surgery.
- The study analyzed data from 383 patients, identifying oligometastatic cases through two definitions: quantitative/anatomical (specific site metastases) and dynamic (percentage based on site), finding relevant statistical significance.
- The results indicated that 30% of patients fit the quantitative definition and 16% the dynamic definition, with outcomes for conversion therapy similar to those who had surgery after initial chemotherapy.
Article Synopsis
- The Italian Research Group for Gastric Cancer created a database to assess how a practical approach influences stage IV gastric cancer management and patient outcomes.
- Data from 383 patients collected between 2018 and September 2022 showed increased use of laparoscopic techniques and a significant difference in surgical treatment strategies compared to past practices.
- The study found that while different metastatic sites didn't significantly affect survival rates, having multiple sites did worsen survival, indicating that better diagnosis and staging can improve outcomes for patients eligible for curative surgery.
Background: Oncologic outcomes after laparoscopic gastrectomy for advanced gastric cancer in the West have been poorly investigated. The aim of the present study was to compare survival outcomes in patients undergoing curative-intent laparoscopic and open gastrectomy for advanced gastric cancer in several centres belonging to the Italian Research Group for Gastric Cancer.
Methods: Data of patients operated between 2015 and 2018 were retrospectively analysed.