[The duration of hormone synthesis by cultures of human fetal endocrine cells].

It is stated as possible to cultivate and accumulate endocrine cells by regular passages in vitro over a long period of time. In this case endocrine cells of human fetus don't loose the ability to synthesize hormone. Such cultures can be used to study some general-biological problems out of influence of the neurohumoral organism factors.

[The morphofunctional properties of the interstitial endocrinocytes of human testes cultured in vitro].

The authors demonstrated the possibility to obtain the pure culture of interstitial endocrinocytes from the testis of human embryo aged 14-24 weeks. Morphofunctional study of in vitro cultures revealed the presence of interstitial endocrinocytes in the monolayer. The ability of these cells to synthesize hormones preserved within the whole period of cultivation was confirmed by an isotope radiology method.

[Correction of alloxan diabetes in rats using xenotransplantation of passaged cultures of human embryonic pancreatic beta cells].

The authors present experimental data on the antidiabetic effect of passaged human embryonic pancreatic beta-cells in their xenotransplantation to rats with alloxan diabetes. Intra-abdominal xenotransplantation of such cultures results in a stable compensation of glycemia in rats with experimental diabetes. These data are important in terms of a possibility to use passaged human embryonic pancreatic beta-cells for transplantation to patients with diabetes mellitus.

[New aspects of the preservation of beta cells from the human fetal pancreas by means of regular passages].

A study was made of the possibility of preserving embryonal beta-cells of the human pancreas up to one year by subcultivation. High insulin-secreting activity of the cultures with many-layered foci in free-floating spherical colonies of beta-cells was recorded.