Publications by authors named "M E Askarian-Amiri"
The development of sustainable and efficient electrochemical processes is crucial for addressing global challenges related to water scarcity. In this study, we present a novel 3D core-shell electrocatalyst, Pt@ZnAl-LDH, supported on low-grade charcoal (LGC), which exhibits exceptional electrocatalytic activity for the degradation and decolorization of dye and the electrocatalytic conversion of glycerol to valuable C chemicals. The electrocatalytic degradation of methylene blue dye from water was investigated with a focus on the impact of temperature, pH, and dye concentration.
View Article and Find Full Text PDFMost human breast cancer cell lines currently in use were developed and are cultured under ambient (21%) oxygen conditions. While this is convenient in practical terms, higher ambient oxygen could increase oxygen radical production, potentially modulating signaling pathways. We have derived and grown a series of four human breast cancer cell lines under 5% oxygen, and have compared their properties to those of established breast cancer lines growing under ambient oxygen.
View Article and Find Full Text PDFIntroduction: Endocrine therapy of breast cancer, which either deprives cancer tissue of estrogen or prevents estrogen pathway signaling, is the most common treatment after surgery and radiotherapy. We have previously shown for the estrogen-responsive MCF-7 cell line that exposure to tamoxifen, or deprivation of estrogen, leads initially to inhibition of cell proliferation, followed after several months by the emergence of resistant sub-lines that are phenotypically different from the parental line. We examined the early responses of MCF-7 cells following either exposure to 4-hydroxytamoxifen or deprivation of estrogen for periods of 2 days-4 weeks.
View Article and Find Full Text PDFArticle Synopsis
- Scientists are using specific cell lines to study breast cancer because they help control experiments, but they also need to understand their limits since breast cancer is complex.
- They looked at 36 popular breast cancer cell lines to see how they behave and found big differences among them, especially in triple-negative lines, which are harder to treat.
- The study created a helpful guide to categorize these cell lines and assist researchers in choosing the right model for their experiments and future studies.