Publications by authors named "M E Angel"
Introduction: Squamous cell carcinoma of the head and neck (SCCHN) is a multifactorial disease involving genetic and environmental factors representing one of the most frequent cancer-related deaths worldwide. Tobacco and alcohol use account for most SCCHN, while a growing subset of oropharyngeal cancers is causally associated with human papillomavirus (HPV) infection. Despite improvements in overall survival, patients with HPV-negative locally advanced (LA) SCCHN continue to have a poor prognosis.
View Article and Find Full Text PDFProstate cancer continues to be one of the most lethal cancers in men. While androgen deprivation therapy is initially effective in treating prostate cancer, most cases of advanced prostate cancer eventually progress to castration-resistant prostate cancer (CRPC), which is incurable. Similarly, the most aggressive form of prostatic carcinoma occurs in dogs that have been castrated.
View Article and Find Full Text PDFArticle Synopsis
- - Enfortumab vedotin (EV) is effective for patients with advanced urothelial carcinoma who have previously received platinum chemotherapy and immune therapy, despite lacking research on those treated with avelumab maintenance.
- - A study of 182 patients showed a median overall survival of 12.7 months and a progression-free survival of 7.9 months, with 39% achieving a positive response to EV after avelumab treatment.
- - The study confirms EV's effectiveness, suggesting it can be a viable option for patients previously treated with avelumab, with manageable side effects like grade ≥ 3 neuropathy and skin rash occurring in a minority of cases.
Article Synopsis
- The study investigates the genomic characteristics of patients with metastatic prostate cancer (mPC), focusing on the genetic testing and outcomes of these patients across various centers worldwide.
- A total of 349 mPC patients from 12 academic centers in five countries were included, with 66.6% undergoing genomic analysis, primarily through multigene panel analyses and next-generation sequencing.
- The findings reveal important progression-free survival (PFS) data, particularly in the metastatic castration-resistant prostate cancer (mCRPC) group, and contribute valuable insights to the understanding of the genomic landscape of advanced prostate cancer in Latin America, which is often underrepresented in clinical trials.
Investigating the structure and etiology of temperament is key to understanding how children interact with the world (Kagan, 1994). Although these topics have yielded an abundance of research, fewer studies have employed observational data during middle childhood, when unique environmental challenges could influence temperament development. To address this gap, Israeli twin children were observed at Age 6.
View Article and Find Full Text PDF