Health Care Resource Use and Costs of Rivaroxaban Versus Warfarin Among Nonvalvular Atrial Fibrillation Polypharmacy Patients With Obesity.

Background: The economic burden of nonvalvular atrial fibrillation (NVAF) is substantial. Many patients with NVAF are obese and manage other health conditions requiring multiple medications. This real-world study compared health care resource use (HRU) and costs for rivaroxaban and warfarin in patients with NVAF who had polypharmacy and obesity.

Chemical succession of naphthenic acid fraction compounds in reclamation landscape mesocosms established on centrifuged and co-mixed fluid fine tailings from the Athabasca oil sands.

The Athabasca oil sands region of Alberta, Canada contains one of the world's largest unconventional petroleum deposits. There is concern about residual contaminants where tailings are integrated during reclamation and the related adverse effects this may have. Some of the primary toxic organic contaminants in oilsands tailings are naphthenic acid fraction compounds (NAFCs).

Leveraging infrared spectroscopy for automated structure elucidation.

The application of machine learning models in chemistry has made remarkable strides in recent years. While analytical chemistry has received considerable interest from machine learning practitioners, its adoption into everyday use remains limited. Among the available analytical methods, Infrared (IR) spectroscopy stands out in terms of affordability, simplicity, and accessibility.

The effect of rhizosphere pH on removal of naphthenic acid fraction compounds from oil sands process-affected water in a willow hydroponic system.

The extraction and processing of bitumen from the oil sands in northern Alberta, Canada generates large volumes of oil sands process-affected water (OSPW). OSPW contains a complex mixture of inorganic and organic compounds, including naphthenic acid fraction compounds (NAFCs) that are of particular concern due to their toxicity to aquatic organisms. Phytoremediation is a cost-effective, scalable approach that has the potential to remove NAFCs from OSPW and reduce OSPW toxicity.

In mild ischemic stroke or high-risk TIA, DAPT started ≤72 h after onset reduced new stroke and increased bleeding at 90 d.

Gao Y, Chen W, Pan Y, et al; INSPIRES Investigators. N Engl J Med. 2023;389:2413-2424.