Publications by authors named "M Duterque-Coquillaud"
Article Synopsis
- The study focused on analyzing 6-month survival rates in patients with acetabular metastasis who underwent total hip arthroplasty using an acetabular cage, examining factors affecting survival and mechanical complications post-surgery.
- A cohort of 93 patients was followed for at least 2 years, with survival rates indicating 78% at 6 months, 66% at 1 year, and 26% at 5 years, while 86% were able to walk again after surgery.
- The research concluded that THA without curettage is an effective treatment for acetabular metastasis, allowing many patients to regain mobility and showing few serious complications.
Prostate cancer, the most common malignancy in men, has a relatively favourable prognosis. However, when it spreads to the bone, the survival rate drops dramatically. The development of bone metastases leaves patients with aggressive prostate cancer, the leading cause of death in men.
View Article and Find Full Text PDFBackground: Neuroendocrine prostate cancer (NEPC) is an aggressive form of prostate cancer, arising from resistance to androgen-deprivation therapies. However, the molecular mechanisms associated with NEPC development and invasiveness are still poorly understood. Here we investigated the expression and functional significance of Fascin-1 (FSCN1), a pro-metastasis actin-bundling protein associated with poor prognosis of several cancers, in neuroendocrine differentiation of prostate cancer.
View Article and Find Full Text PDFOlder age is one of the strongest risk factors for severe COVID-19. In this study, we determined whether age-associated cellular senescence contributes to the severity of experimental COVID-19. Aged golden hamsters accumulate senescent cells in the lungs, and the senolytic drug ABT-263, a BCL-2 inhibitor, depletes these cells at baseline and during SARS-CoV-2 infection.
View Article and Find Full Text PDFCoronavirus disease 2019 (COVID-19, caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)) is primarily a respiratory illness. However, various extrapulmonary manifestations have been reported in patients with severe forms of COVID-19. Notably, SARS-CoV-2 was shown to directly trigger white adipose tissue (WAT) dysfunction, which in turn drives insulin resistance, dyslipidemia, and other adverse outcomes in patients with COVID-19.
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