Publications by authors named "M Duru"
Objective: Lung cancer is the primary cause of cancer-related deaths globally. Protein kinase B (AKT) protein is associated with many pathways in non-small cell lung cancer (NSCLC), such as proliferation, migration, invasion, and apoptosis. Mushrooms have a long history of being used in traditional medicine to treat various diseases.
View Article and Find Full Text PDFThe current study aims to prepare a green extract using a new method in addition to conventional extraction methods including; methanolic and ultrasonic extraction of , to compare their phenolic composition utilizing high-performance liquid chromatograph equipped with a diode array detector (HPLC-DAD), anti-bacterial, anti-oxidant, and enzyme inhibition activities. The results of HPLC-DAD analysis showed that Rosmarinic acid was found the highest amount in the methanolic extract followed by ultrasonic and green extracts as 169.7 ± 0.
View Article and Find Full Text PDFArticle Synopsis
- - Mushrooms are nutritious with high protein and healthy fats, and they are being researched for their health benefits and potential industrial applications, particularly their natural compounds.
- - The study explored the cytotoxic effects of different extracts from the mushroom on various cancer cell lines using various scientific assays, finding that the hexane extract was most effective against A549 cells, while methanol extract showed considerable efficacy against PC-3 cells.
- - Additionally, the methanol extract exhibited strong antioxidant activity and reduced inflammatory markers (like TNF-α and VEGF), while the hexane extract displayed notable antimicrobial properties against several pathogens.
Article Synopsis
- The research focuses on the benefits of natural product-based therapies, particularly emphasizing the healthful properties of a common spice used in Algeria, (L.) Ach., through various extract evaluations.
- Key findings revealed the presence of significant phenolic compounds such as rosmarinic acid and caffeic acid, alongside strong antioxidant and anti-inflammatory activities linked to both aqueous and methanolic extracts.
- The methanolic extract demonstrated notable cytotoxic effects on human cancer cells while showing no harm to non-tumor cells, suggesting its potential as a natural therapeutic agent.
The association between change in temporal muscle mass and treatment of acromegaly.
Growth Horm IGF Res
December 2024
Purpose: We aimed to evaluate the relationship between temporal muscle thickness and GH/IGF-1 elevation and the effect of acromegaly treatment on temporal muscle thickness.
Methods: Patients with acromegaly and healthy controls were included in the study. While laboratory parameters, clinical findings and temporal muscle thickness of acromegaly patients at the time of diagnosis and one year after treatment were evaluated, laboratory parameters and temporal muscle thickness of healthy controls were evaluated only during the period when they were included in the study.