Serum butyrylcholinesterase activities in patients with non-alcoholic fatty liver disease. Comparison with liver proteosynthetic function and liver fibrosis.

Background: We aimed to determine how does butyrylcholinesterase (BChE) activity change in the serum of NAFLD patients, whether there was a relationship between BChE and the severity of NAFLD and whether BChE could be used to distinguish the patients with simple hepatic steatosis from the patients with non-alcoholic steatohepatitis.

Methods: The study group consisted of 64 patients with NAFLD. Patients were examined for fatty liver index and in the serum, we investigated BChE activities and the concentrations of prealbumin, cholesterol, HDL-cholesterol, triacylglycerols and hyaluronic acid (HA).

Mini-Review: Is iron-mediated cell death (ferroptosis) an identical factor contributing to the pathogenesis of some neurodegenerative diseases?

The review article briefly discusses a hypothesis based on the potential participation of iron dyshomeostasis and iron-mediated cell death (ferroptosis) in the pathogenesis of some neurodegenerative diseases. Iron dyshomeostasis (especially cellular iron overload) is considered to be a critical condition of neurodegeneration. The etiopathogenesis of many neurodegenerative diseases including Alzheimer's and Parkinson's diseases, Multiple sclerosis, and others, is different.

Can alpha-1-acid glycoprotein affect the outcome of treatment in a cancer patient?

Alpha-1-acid glycoprotein (AGP) is a glycoprotein found in the alpha-1 globulin fraction of human plasma proteins. AGP is an important representative of acute-phase proteins. Although numerous articles have been devoted to AGP, its exact biological function remains obscure.

Cholesterol level correlate with disability score in patients with relapsing-remitting form of multiple sclerosis.

Background: Multiple sclerosis (MS) is an autoimmune disease characterised by demyelination. There are many environmental factors that can affect the progression of this disease. It is necessary to better understand the impact of these factors in MS pathogenesis and progression.