Publications by authors named "M Dukhinova"
Article Synopsis
- - Cockayne syndrome group B (CSB) is caused by mutations in the genes responsible for producing the CSB protein, leading to symptoms like growth failure, microcephaly, photosensitivity, and signs of premature aging.
- - Neurological issues in CSB include brain atrophy, demyelination, and calcification, primarily affecting the cerebellum and basal ganglia, causing movement disorders like dyskinesia and ataxia.
- - The review highlights the need to understand the CSB protein's structure and function, discusses the limited neurodevelopmental insights from current animal models, and emphasizes the potential of brain organoids in future research on CS disorders.
Developing biocompatible, magnetically controlled polymers is a multifunctional solution to many surgical complications. By combining nanoparticle technology with the latest advancements in polymer materials science, we created a multicomponent hybrid system comprised of a robust native spider silk-based matrix; a MnZnFeO nanoparticles coating to provide a controlled thermal trigger for drug release; and liposomes, which act as drug carriers. Fluorescent microscope images show that the dye loaded into the liposomes is released when the system is exposed to an alternating magnetic field due to heating of ferromagnetic nanoparticles, which had a low Curie temperature (40-46°С).
View Article and Find Full Text PDFHyperactivation of the immune system remains a dramatic, life-threatening complication of viral and bacterial infections, particularly during pneumonia. Therapeutic approaches to counteract local and systemic outbreaks of cytokine storm and to prevent tissue damage remain limited. Cyclin-dependent kinases 8 and 19 (CDK8/19) potentiate transcriptional responses to the altered microenvironment, but CDK8/19 potential in immunoregulation is not fully understood.
View Article and Find Full Text PDFTreatment of drug-resistant forms of cancer requires consideration of their hallmark features, such as abnormal cell death mechanisms or mutations in drug-responding molecular pathways. Malignant cells differ from their normal counterparts in numerous aspects, including copper metabolism. Intracellular copper levels are elevated in various cancer types, and this phenomenon could be employed for the development of novel oncotherapeutic approaches.
View Article and Find Full Text PDFArticle Synopsis
- Surgical interventions in the head and neck can affect how ischemic changes occur in the brain, impacting both their nature and location.
- The review focuses on comparing the timing of basic cellular and molecular processes involved in these changes.
- Criteria for selecting animal models include oxidative stress in brain cells, blood-brain barrier issues, glial activation, neuroinflammation, changes in blood vessel growth, and the model's reproducibility.