Crystal structure determination is a crucial aspect of almost every branch of the chemical sciences, bringing us closer to understanding crystallization, polymorphism, phase transitions, and the relationship between a structure and its physicochemical and functional properties. Unfortunately, many molecules notoriously crystallize as microcrystalline powders, providing a significant challenge in establishing their structures. In this work, we describe the crystal structure determination of three elusive polymorphs of the anti-inflammatory drug meloxicam (MLX) using three approaches, of which only one was successful for each crystal phase.
View Article and Find Full Text PDFObjective: Aim: Bladder disorders are one of the most troubling symptoms of Multiple Sclerosis (MS), which impact patients quality of life (QoL). Therefore the aim of this pilot study was to assess this problem.
Patients And Methods: Materials and Methods: 47 patients (28 females and 19 males, aged 40,8±12,2 years; EDSS 3,2±1,9) diagnosed with Relapsing Remitting Multiple Sclerosis (RRMS) during disease modifying treatment (DMT) were enrolled to our study.