The nervous system's regenerative potential has sparked interest in exploring novel approaches to generate Schwann cell-like cells (SC-LCs) from chicken blastoderm (B)-derived embryonic stem cells (B-ESCs). This study investigates the hypothesis that specific growth factors, when used during ex-ovo culture, can induce the differentiation of chicken B-ESCs into cells resembling Schwann cells (SCs). Blastodermal cells (BCs) were isolated from in vivo-fertilized eggs at stage X followed by 14-d proliferative culture (PRC) of B-ESCs and subsequent 14-d glial/neurolemmogenic differentiation culture (DFC).
View Article and Find Full Text PDFACS Appl Mater Interfaces
November 2024
Fluorescent nanothermometers are positioned to revolutionize research into cell functions and provide strategies for early diagnostics. Fluorescent nanostructures hold particular promise to fulfill this potential if nontoxic, stable varieties allowing for precise temperature measurement with high thermal sensitivities can be fabricated. In this work, we investigate the performance of micelle-encapsulated CuInS/ZnS core/shell colloidal quantum dots (QDs) as fluorescent nanothermometers.
View Article and Find Full Text PDFStrong tolerance to off-stoichiometry of group I-III-VI semiconductors in their nanocrystal form allows fabrication of multinary, alloyed structures of desired properties. In particular, alloyed Cu-In-Zn-S and Ag-In-Zn-S quantum dots (QDs) have recently emerged as efficient fluorophors, in which tailoring the composition allows tuning the optical properties, and achieving photoluminescence (PL) quantum yields approaching unity. However, poor understanding of the carrier recombination mechanism in these materials limits their further development.
View Article and Find Full Text PDFStearoyl-CoA desaturase (SCD) is a lipogenic enzyme that catalyzes formation of the first double bond in the carbon chain of saturated fatty acids. Four isoforms of SCD have been identified in mice, the most poorly characterized of which is SCD4, which is cardiac-specific. In the present study, we investigated the role of SCD4 in systemic and cardiac metabolism.
View Article and Find Full Text PDFDiatoms are key components of freshwater ecosystems and are regularly used for paleolimnological reconstructions, in which defining species optima and tolerances is fundamental for interpreting assemblage shifts in a sediment record. Here, we examined responses of diatoms across three major environmental gradients-dissolved inorganic carbon (range: 0.1-230.
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