[Integrins and prolidase activity in uterine leiomyoma during tumor growth].

Collagens and proteoglycans are the main components of connective tissue. Prolidase plays an important role in the balance between collagen biosynthesis and degradation and its activity reflects the rate of collage turn-over. The activity of this enzyme is known to be regulated by interaction of collagen with beta 1 integrin receptor.

Accumulation of collagen in ovarian benign tumours.

Extracellular matrix components of benign ovarian tumours (cystadenoma, adenofibroma, cystadenofibroma) were analysed. The investigated tumours contained twice as much collagen than control ovarian tissues. Significant alterations in mutual quantitative relationships between collagens of various types were observed.

[Extracellular matrix components in ovarian tumors].

This report describes the collagen, glycosaminoglycans and elastin--composition of ovarian tumours. Rearrangement of extracellular matrix in ovarian tumour has been found. There was an increase of total collagen content in comparison to control.

Extracellular matrix components in uterine leiomyoma and their alteration during the tumour growth.

It was found that both normal human myometrium and uterine leiomyoma contain several glycosaminoglycans. In contrast to many normal and tumour tissues the amount of hyaluronic acid is very low and the proportional amount of sulphated glycosaminoglycans is distinctly higher. It is of interest that heparan sulphate is the major glycosaminoglycan component both in normal myometrium, and in leiomyoma.

[Extracellular matrix components in leiomyosarcoma].

This report describes the glycosaminoglycans, collagen and elastin--composition of leiomyosarcoma. Studies were performed on leiomyosarcoma removed during surgery. The material was taken from 7 patients.