Publications by authors named "M Dreyer"
Background: Experimental knee implant wear testing according to ISO 14243 is a standard procedure, but it inherently possesses limitations for preclinical evaluations due to extended testing periods and costly infrastructure. In an effort to overcome these limitations, we hereby develop and experimentally validate a finite-element (FE)-based algorithm, including a novel cross-shear and contact pressure dependent wear and creep model, and apply it towards understanding the sensitivity of wear outcomes to the applied boundary conditions.
Methods: Specifically, we investigated the application of in vivo data for level walking from the publicly available "Stan" data set, which contains single representative tibiofemoral loads and kinematics derived from in vivo measurements of six subjects, and compared wear outcomes against those obtained using the ISO standard boundary conditions.
Article Synopsis
- In early-stage triple-negative breast cancer (TNBC), high glucocorticoid receptor (GR) expression is linked to poor outcomes, potentially due to an immunosuppressed tumor microenvironment.
- A study of 47 patients showed that high GR expression correlated with increased levels of immunosuppressive FOXP3+ regulatory T cells and BATF3+ immune cells, but not significantly with CD8+ T cell infiltration.
- The findings suggest that high GR expression may contribute to a more immunosuppressed state in TNBC, which could explain worse prognoses for patients with GR-positive tumors.
Background: Doublet platinum or taxane-based therapies are the current standard backbone of treatment for advanced gastric/gastroesophageal junction (GEJ) adenocarcinoma. Previously used anthracycline-based triplet regimens are no longer used routinely due to toxicity and lack of superior efficacy. We hypothesized that the addition of nab-paclitaxel to FOLFOX (FOLFOX-A) would induce higher efficacy and better tolerability.
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