Synthesis and characterization of some new bishydrazones derived from isatin.

Unlabelled: The scientific literature states that isatin and its derivatives exhibit antibacterial, antifungal, anticonvulsant, cytotoxic and anti-HIV activities. The aim of our study was to enlarge the number of isatin derivatives.

Material And Method: We synthesized some new hydrazones and then, the corresponding bishydrazones using salicylaldehyde.

[New isatin-derived hydrazones and Mannich bases with possible biological activity].

The paper presents a synthesis of six new Mannich bases, five hydrazones derived from 1-piperidino-methyl-5-R-isatin and three copper complex compounds of 3-(3'-R-phenyl-pyridazinil-hydrazone)-indoline-2-ones (R=H, CH3, OCH3). The structure of the new compounds was confirmed by the results of the elementary and spectral analysis. Pharmacodynamic studies indicated that copper complex compounds present effective biological properties.

[The reaction of 3-(R-phenyl)-6-hydrazine pyridazines with substituted isatins (II)].

This paper presents the synthesis of six hydrazones from isatin and 1-morpholinomethyl-isatin and also of their six cooper's complex salts. Their structure was confirmed by the results of the quantitative elemental analysis and by IR, UV-VIS spectral analysis. The biological tests point out that cooper's complex salt of 3-(3'-phenyl-pyridazinylhydrazono)-5-methyl-indoline-2-one (1:2) (VI a) has the smallest toxicity (DMT over 800 mg/kg.

Tetrazolium salts and metal complexes of some formazans.

This paper presents the synthesis of some tetrazolium salts and metal complexes combinations, which are derived from aromatic and heterocyclic formazans. Elemental quantitative analyses and spectral data confirmed the structure of the new synthesized compounds. The new synthesized compounds were submitted to microbiological tests.

Hydrazones and formazans with possible biological activity.

This paper presents a synthesis about some hydrazones, formazans and copper's complexes combinations. The structure of the new compounds was confirmed by the results of the quantitative elementary and IR spectral analysis. The antimicrobial and antiinflammatory activities were investigated.