Cysteine Rich Intestinal Protein 2 is a copper-responsive regulator of skeletal muscle differentiation and metal homeostasis.

Copper (Cu) is essential for respiration, neurotransmitter synthesis, oxidative stress response, and transcription regulation, with imbalances leading to neurological, cognitive, and muscular disorders. Here we show the role of a novel Cu-binding protein (Cu-BP) in mammalian transcriptional regulation, specifically on skeletal muscle differentiation using murine primary myoblasts. Utilizing synchrotron X-ray fluorescence-mass spectrometry, we identified murine cysteine-rich intestinal protein 2 (mCrip2) as a key Cu-BP abundant in both nuclear and cytosolic fractions.

Foot Reflexology with Caring Consciousness to Reduce Pain in Older Adults: An Integrative Review.

To analyze the evidence available on foot reflexology with application of caring consciousness to reduce pain in older adults Integrative review carried out in Medline/PubMed, CINAHL, EBSCO Host, SCOPUS, Web of Science, and EMBASE databases using the MESH terms "Aged," "Pain," "Musculoskeletal manipulations," "Nursing," and "Nursing theory." in English, Spanish, Portuguese, and French published between 2012 and 2022. The selected studies were exported to Rayyan software and evaluated by title and abstract; after reading the full text, were analyzed according to the PRISMA guide checklist.

Bismuth-based nanocomposites as potential materials for indoor air treatment.

Air pollution is a worldwide health hazard; thus, improving air quality is a demanding need. Photocatalysis is a robust strategy for air treatment. The boosted activity of the photocatalytic system depends on tuning their properties for the particular application.

Dubbing language-therapy CINEma-based in aphasia post-stroke (DULCINEA): A feasibility randomized crossover controlled trial.

Background: Helping people recover from aphasia is among the top 10 research priorities relating to life after stroke.

Objective: We aimed to evaluate the feasibility of dubbing techniques (using newly developed software) for post-stroke aphasia therapy and explore its potential efficacy.

Methods: Randomised, crossover, interventional, feasibility trial that included patients with chronic post-stroke non-fluent aphasia.

Partial Recovery of Telomere Length After Long-term Virologic Suppression in Persons With HIV-1.

Background: People with HIV-1 (PWH) age differently than the general population. Blood telomere length (BTL) attrition is a surrogate biomarker of immunosenescence and aging in PWH. BTL is reduced immediately after HIV-1 infection and recovers in PWH with long-term virologic suppression, but the extent of this recovery is unknown.