Alzheimers Dement
December 2024
Background: It is common for individuals under the age of 65 to consult neurologists for cognitive complaints ranging from subjective cognitive issues to mood disorders that affect cognitive function. The challenge is rule out attention deficit hyperactivity disorders, other psychiatric causes, and cognitive impairment. In 2020, the Lancet Commission released a report analyzing 12 modifiable risk factors (MRFs) by age group.
View Article and Find Full Text PDFBackground: Genetic testing for individuals with dominantly inherited Alzheimer's disease (DIAD) is now of greater relevance due to the existence of therapeutic trials available to this population. However, the impact and main drivers influencing the decision to seek genetic testing are relatively unknown in Latin America (LatAm). Here we present results from a regional genetic counseling and testing protocol implemented in LatAm.
View Article and Find Full Text PDFIntroduction: The ability of healthcare, community and public health systems to effectively implement and disseminate research innovations depends on contextual factors at multiple interconnected levels of influence (eg, the innovation, individual, provider/implementor, organisation and health system). Recently, there has been an increase in the development of complex interventions designed to target multiple levels, designed for or adapted to the context in which they are delivered. Two concepts from complex systems thinking have been increasingly used to operationalise such interventions-core functions (theory and evidence-driven purposes of interventions) and forms (adaptable activities that perform each core function).
View Article and Find Full Text PDFBackground: One factor considered essential to successful implementation is organizational readiness. The purpose of this study was to explore ways to improve the measurement of organizational readiness, and in particular to refine a preliminary measure based on the Readiness = Motivation x innovation Specific Capacity x General Capacity (R = MC2) heuristic. We assessed the experiences of staff in Federally Qualified Health Centers (FQHC) implementing evidence-based interventions (EBIs) designed to increase colorectal cancer screening (CRCS) who previously completed the survey and aimed to understand their perspectives on why our data were positively skewed.
View Article and Find Full Text PDFBackground/objectives: In the framework of the ValueCare project (funded by EC, ref 875215), the Valencia pilot site assessed the comprehensive health of 240 older people with frailty. ValueCare aims to deliver personalised integrated health and social care and better outcomes for older people.
Methods: For the health evaluation, a comprehensive approach was adopted, based on validated questionnaires that address not only mental and physical health but also other key dimensions in older people's well-being, namely unwanted loneliness and nutrition.