Publications by authors named "M Dolores Cimini"
Mesenchymal stromal cells (MSC) are promising stem cell therapy for treating cardiovascular and other degenerative diseases. Diabetes affects the functional capability of MSC and impedes cell-based therapy. Despite numerous studies, the impact of diabetes on MSC myocardial reparative activity, metabolic fingerprint, and the mechanism of dysfunction remains inadequately perceived.
View Article and Find Full Text PDFMicrogravity exposure induces a cephalad fluid shift and an overall reduction in physical activity levels which can lead to cardiovascular deconditioning in the absence of countermeasures. Future spaceflight missions will expose crew to extended periods of microgravity among other stressors, the effects of which on cardiovascular health are not fully known. In this study, we determined cardiac responses to extended microgravity exposure using the rat hindlimb unloading (HU) model.
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- Amyloidosis is linked to chronic diseases, and this study investigates its role as a complication following a myocardial infarction (MI), highlighting the need for further understanding.
- The research utilized mouse models to reveal that macrophages produce excessive amounts of Serum Amyloid A 3 (SAA3) protein after MI due to communication with activated mesenchymal stromal cells (MSC), which alter their behavior in response to heart injury.
- Results indicate that the aggregation of SAA3 proteins into amyloid deposits makes the heart scar tissue stiffer, reducing heart function post-MI; however, targeting SAA3 aggregation with a specialized D-peptide shows potential for improving heart health after an MI.
Background: Heart failure (HF) is one of the leading causes of mortality worldwide. Extracellular vesicles, including small extracellular vesicles or exosomes, and their molecular cargo are known to modulate cell-to-cell communication during multiple cardiac diseases. However, the role of systemic extracellular vesicle biogenesis inhibition in HF models is not well documented and remains unclear.
View Article and Find Full Text PDFHistorically, a lower incidence of cardiovascular diseases (CVD) and related deaths in women as compared with men of the same age has been attributed to female sex hormones, particularly estrogen and its receptors. Autologous bone marrow stem cell (BMSC) clinical trials for cardiac cell therapy overwhelmingly included male patients. However, meta-analysis data from these trials suggest a better functional outcome in postmenopausal women as compared with aged-matched men.
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