NHC-BIAN-Cu(I)-Catalyzed Friedländer-Type Annulation of 2-Amino-3-(per)fluoroacetylpyridines with Alkynes on Water.

The direct catalytic alkynylation/dehydrative cyclization of 2-amino-3-trifluoroacetyl-pyridines on water was developed for the efficient synthesis of a broad range of fluorinated 1,8-naphthyridines from terminal alkynes. A novel N-heterocyclic carbene (NHC) ligand system that combines a π-extended acenaphthylene backbone with sterically bulky pentiptycene pendant groups was successfully utilized in a copper- or silver-mediated cyclization. Computational analysis of the reaction pathway supports our explanation of the different experimental conversions and yields for the set of copper and silver catalysts.

[Mental disorders during pregnancy and postpartum period--epidemiology, etiology, classification and treatment].

The paper presents current knowledge about the prevalence of mental disorders during pregnancy and postpartum period and its' classification. Possible pathomechanisms of its incidence, risk factors and therapeutic possibilities based on the newest research were described.

[Use of a dynamic test with HCG for evaluation of endocrine function in gonads of men with chronic alcohol abuse].

We studied 40 chronic alcoholic men (aged 39 +/- 11) after alcohol withdrawal. We excluded in these patients severe internal organs disorders (first of all liver dysfunction) and seminal pathology. We analysed (in HCG test) plasma levels of: luteinizing hormone--LH, follicle stimulating hormone--FSH, total testosterone--T, free testosterone--fT, estradiol--E, 17-OH progesterone, sex hormone binding globulin--SHBG.