Publications by authors named "M Doffoel"
Article Synopsis
- Hepatitis Delta virus (HDV) significantly contributes to liver-related health issues in patients with HBV, prompting France to enhance testing for anti-HDV antibodies in HBsAg-positive individuals since January 2022.
- A study comparing six years of serology data showed a more than 2-fold increase in HDV diagnoses among HBsAg carriers and a notable rise in anti-HDV positive rates from 6.8% to 10.3% overall.
- The improved testing strategy has allowed for earlier identification of HBV-HDV co-infected patients, enabling timely referrals to specialists and potential treatment with bulevirtide, signaling promising outcomes for patient management.
Background And Aims: People who use drugs (PWUDs) are the main group at risk for hepatitis C virus (HCV) transmission and a key population for hepatitis C elimination. Multidisciplinary team (MDT) meetings were set up in France in December 2014 within regional reference centers to supervise the prescriptions and delivery of direct-acting antivirals (DAAs) to optimize the management of HCV infection. The aim of this retrospective study was to analyze the changes in the profile and therapeutic care of PWUDs with HCV mono-infection according to the evolution of MDT meetings in a regional tertiary reference center.
View Article and Find Full Text PDFIntroduction: Significant hepatocellular carcinoma (HCC) risk persists after chronic hepatitis C (CHC) cure. Preclinical studies have shown that erlotinib, an oral epidermal growth factor receptor (EGFR) inhibitor, has an antiviral activity and HCC chemopreventive effect. Erlotinib is metabolized in the liver, and its safety in patients with CHC is unknown.
View Article and Find Full Text PDFBackground And Aims: Coronavirus disease 2019 (COVID-19) is a serious public health issue that became rapidly pandemic. Liver injury and comorbidities, including metabolic syndrome, are associated with severe forms of the disease. This study sought to investigate liver injury, clinical features, and risk factors in patients with mild, moderate, and severe COVID-19.
View Article and Find Full Text PDFBackground And Aims: Hepatitis C is poorly documented in migrants. The published studies mainly concern the screening in this population and are limited to some countries in Europe and North America. This study aimed to evaluate the characteristics and care of chronic hepatitis C in this population compared to the nonmigrant population, in the era of direct-acting antivirals (DAAs).
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