Iris cavernous hemangioma associated with multiple cavernous hemangiomas in the kidney, brain, and skin.

Purpose: To document the relationship of iris cavernous hemangiomas with multiorgan hemangiomas in a child.

Methods: A 7-year-old girl with kidney hemangiomas, brain hemangiomas, and skin hemangiomas developed blurred vision and darkening of the right iris. She had undergone 6 previous brain surgeries and multiple revisions of a ventriculoperitoneal shunt for hydrocephalus beginning at age 3 months.

Viral safety and clearance evaluation--implications for process change and comparability.

A key component in the development of safe cell-based biologicals is the incorporation of procedures to ensure virological safety using a three-pronged approach--raw material testing, including testing of the cell banks; incorporation of virus clearance steps in the production process; and lot-by-lot virus testing of culture harvests. During the development of a biological, changes are made to improve product quality, purity, yield, and consistency and to meet other production requirements. It is important to evaluate process changes in view of virus safety.

Sudden painless visual loss.

Common signs and symptoms of temporal arteritis include headache, scalp tenderness, jaw claudication, anemia, and an elevated sedimentation rate (ESR). Severe complications can include blindness, retinal artery occlusion, and optic neuropathy. While temporal arteritis may be suggested by patient history, other causes that can mimic its presentation must be considered, especially when visual loss occurs in the setting of a normal funduscopic exam.