Hematological Changes in Clozapine Users: A Study in a Brazilian Community Sample.

Introduction: Clozapine is the only antipsychotic with proven superior efficacy for treatment-resistant schizophrenia. However, global utilization rates remain suboptimal due to concerns about hematological side effects. This study aimed to investigate hematological abnormalities among clozapine users at a large community center in the Brazilian countryside.

Guest Diffusion Versus Recrystallization in A Single Crystal: Two Growing Mechanisms for Griseofulvin Clathrates.

Griseofulvin represents a rare case of a close-packed organic apohost that can clathrate selected volatile guests in a solid-gas fashion. Inclusion mechanisms and solvent exchange were investigated by a combination of single crystal and powder X-ray diffraction, coupled to optical microscopy and thermal analyses. In particular, gas diffusion and dissolution/recrystallization are alternatively observed, depending on the host polymorph, as well as the chemical nature of the guest and its physical state.

Effect of curcumin and three analogues on pre-osteoblast cells' viability, differentiation, and gene expression.

Curcumin, found in turmeric rhizomes (Curcuma longa L.), has been widely studied for its potential health benefits, including anti-inflammatory, antioxidant, and wound-healing properties. However, due to its low bioavailability and unfavorable pharmacokinetics, analogous compounds have been developed to obtain better biopharmaceutical characteristics and enhanced biological effects.

Metazoan parasite community of Leporinus piau Fowler, 1941 (Anostomidae, Characiformes), an endemic freshwater fish from the Caatinga domain, Brazil.

The present study aimed to inventory the parasitic fauna of Leporinus piau from the Lima Campos weir, Salgado River basin, municipality of Icó, Ceará, Brazil. A total of 35 host specimens were collected, whereas all were parasitized by at least two metazoan taxa. A total of 2,910 parasite specimens belonging to five taxonomic groups were identified such as: Myxozoa (Henneguya sp.