In vivo assessment of safety, biodistribution, and radiation dosimetry of the [F]Me4FDG PET-radiotracer in adults.

Background: Approaches targeting the sodium-glucose cotransporter (SGLT) could represent a promising future therapeutic strategy for numerous oncological and metabolic diseases. In this study, we evaluated the safety, biodistribution and radiation dosimetry of the glucose analogue positron emission tomography (PET) agent [F] labeled alpha-methyl-4-deoxy-4-[F]fluoro-D-glucopyranoside ([F]Me4FDG) with high sodium-glucose cotransporter and low glucose transporter (GLUT) affinity. For this purpose, five healthy volunteers (1 man, 4 women) underwent multiple whole-body PET/computed tomography (CT) examinations starting with injection and up to 4 h after injection of averaged (2.

Internal dosimetry study of [Rb]Cl using a long axial field-of-view PET/CT.

Purpose: Long axial field-of-view (LAFOV) positron emission tomography (PET) systems allow to image all major organs with one bed position, which is particularly useful for acquiring whole-body dynamic data using short-lived radioisotopes like Rb.

Methods: We determined the absorbed dose in target organs of three subjects (29, 40, and 57 years old) using two different methods, i.e.

Validation of quantitative assessment of florbetaben PET scans as an adjunct to the visual assessment across 15 software methods.

Purpose: Amyloid positron emission tomography (PET) with [F]florbetaben (FBB) is an established tool for detecting Aβ deposition in the brain in vivo based on visual assessment of PET scans. Quantitative measures are commonly used in the research context and allow continuous measurement of amyloid burden. The aim of this study was to demonstrate the robustness of FBB PET quantification.

Comparing calculated and experimental activity and dose values obtained from image-based quantification of Y SPECT/CT Data.

Purpose: Selective internal radiation therapy (SIRT) is a treatment for various kinds of liver tumours by injecting Y bearing microspheres into the liver vessels. To perform meaningful post-treatment dosimetry, quantitative imaging is performed.

Methods: This work uses a Monte-Carlo based reconstruction software with scatter and attenuation correction and collimator modelling that allows the quantification of Y bremsstrahlung SPECT/CT data.

Glomerular Filtration Rate and Error Calculation Based on the Slope-Intercept Method with Chromium-51 Ethylenediaminetetraacetic Acid via a New Clinical Software: GFRcalc.

Objective: To evaluate a home-built Java-based program (GFRcalc) to simplify the calculation of glomerular filtration rate (GFR) after administration of chromium-51 ethylenediaminetetraacetic acid (51Cr-EDTA) for routine clinical use.

Materials And Methods: In the program GFRcalc, the GFR was calculated based on the biological half-life of the 51Cr-EDTA concentration using the slope-intercept method of between two and five blood samples. Additional features included the ability to export patient data and generate clinical reports as well as to calculate the error of the fit of the GFR measurement in cases with three or more blood samples collected.