Partisan animosity has been growing in the United States and around the world over the past few decades, fueling efforts by researchers and practitioners to help heal the divide. Many studies have been conducted to test interventions that aim to promote open-mindedness; however, these studies have been conducted in disparate literatures that do not always use the same terminology. In this review, we integrate research on open-mindedness in order to facilitate cross-talk and collaboration between disciplines.
View Article and Find Full Text PDFUnlabelled: Microenvironment niches determine cellular fates of metastatic cancer cells. However, robust and unbiased approaches to identify niche components and their molecular profiles are lacking. We established Sortase A-Based Microenvironment Niche Tagging (SAMENT), which selectively labels cells encountered by cancer cells during metastatic colonization.
View Article and Find Full Text PDFUnderstanding the socio-political attitudes of other people is a crucial skill, yet the neural mechanisms supporting this capacity remain understudied. This study used multivariate pattern analysis to examine patterns of activity in the default mode network (DMN) while participants assessed their own attitudes and the attitudes of other people. Classification analyses indicated that common patterns in DMN regions encode both own and others' support across a variety of contemporary socio-political issues.
View Article and Find Full Text PDFAdolescence is characterized by biological changes in hormonal and circadian systems that, with concurrent psychosocial changes, result in increased sleep disturbances and stress sensitivity. Sleep disturbance has been associated with heightened stress sensitivity and elevated levels of inflammation in adults and adolescents, yet the neural correlates are unknown in adolescents. The current study investigated whether and how individual differences in peripheral immune markers (IL-6, TNF-α) related to neural response to stress in adolescents and whether these immune-brain associations were moderated by adolescents' sleep duration.
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