Publications by authors named "M Diedisheim"
Context: Type 1 diabetes (T1D) is characterized by the presence of autoantibodies on a genetic background largely determined by HLA class II haplotypes. Stage 1 T1D is characterized by the presence of multiple autoantibodies and normoglycemia.
Objective: To investigate the prevalence of high-risk HLA-DQB1 haplotypes and the extent of islet autoimmunity in pancreatic tissues from non-diabetic organ donors with autoantibodies.
The mechanisms governing adipose tissue macrophage (ATM) metabolic adaptation during diet-induced obesity (DIO) are poorly understood. In obese adipose tissue, ATMs are exposed to lipid fluxes, which can influence the activation of specific inflammatory and metabolic programs and contribute to the development of obesity-associated insulin resistance and other metabolic disorders. In the present study, we demonstrate that the membrane ATP-binding cassette g1 (Abcg1) transporter controls the ATM functional response to fatty acids (FAs) carried by triglyceride-rich lipoproteins, which are abundant in high-energy diets.
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- - The study investigates the role of the enzyme ELOVL5 in the biosynthesis of Polyunsaturated Fatty Acids (PUFAs) and its implications for liver conditions, specifically MASH (metabolic-associated steatotic liver disease), revealing how enzyme disruption affects liver metabolism.
- - Research showed that ELOVL5 levels increase during MASH progression and that its absence in mice leads to significant liver issues after a high-fat, high-sucrose diet, including fat accumulation, inflammation, and fibrosis.
- - The findings suggest that the loss of ELOVL5 disrupts mitochondrial function, contributes to liver damage from dietary factors, and alters fatty acid metabolism, indicating a critical link between enzyme activity and liver health.
Article Synopsis
- Chronic high cholesterol levels lead to systemic immune responses that accelerate atherosclerosis, but the impact of alternating high-fat diets (HFD) had not been well studied.
- Researchers used a mouse model to compare the effects of an alternating HFD versus a continuous HFD on atherosclerosis progression, finding that the alternating diet significantly worsened the condition.
- The study revealed that this worsening was linked to IL-1β production, which triggered inflammatory responses and increased neutrophil levels that contributed to plaque formation and exacerbated atherosclerosis, suggesting that targeting these pathways could reverse the effects.
Article Synopsis
- Diabetes significantly increases the risk of cardiovascular diseases, particularly among individuals with type 2 diabetes (T2D), where circulating monocytes play a crucial role in inflammation related to both diabetes and atherosclerosis.* -
- A study involving 672 T2D patients found a positive correlation between blood monocyte counts and coronary artery calcium scores, which are indicators of cardiovascular risk, revealing distinct monocyte subtypes associated with varying cardiovascular risk levels.* -
- The research indicates that analyzing monocyte frequency and profiles can serve as valuable predictors for cardiovascular events in T2D patients, highlighting potential mitochondrial dysfunction in these individuals' immune responses.*