Publications by authors named "M Didi"
Biomarkers and Diagnostic Thresholds for Congenital Hyperinsulinism.
Clin Endocrinol (Oxf)
February 2025
Article Synopsis
- - The study investigates Congenital Hyperinsulinism (CHI), focusing on finding a reliable C-peptide level threshold for accurate diagnosis in hypoglycemic children.
- - Researchers conducted a retrospective analysis of data from a children's hospital, comparing C-peptide, insulin, free fatty acids, and B-hydroxybutyrate levels between CHI patients and those with other conditions.
- - Results revealed a significant difference in median C-peptide levels (147 pmol/L for CHI vs. 72 pmol/L for non-CHI), suggesting that a C-peptide value above 291.5 pmol/L effectively indicates CHI, enhancing its role as a valuable diagnostic test.
This retrospective study, conducted over five years, aimed to assess the bacteriological profile of nosocomial pneumonia, the antibiotic resistance of isolated bacteria, and changes in these parameters over time. The analysis reviewed 660 samples from the microbiology department at the Military Hospital of Avicenne in Marrakech, Morocco, covering the period from January 1, 2017, to December 31, 2021. Among these samples, 303 microorganisms were identified from 251 specimens, confirming diagnoses of nosocomial pneumonia.
View Article and Find Full Text PDFContext: In focal congenital hyperinsulinism (CHI), localized clonal expansion of pancreatic β-cells causes excess insulin secretion and severe hypoglycemia. Surgery is curative, but not all lesions are amenable to surgery.
Objective: We describe surgical and nonsurgical outcomes of focal CHI in a national cohort.
Context: Meta-analyses report that the low dose short Synacthen test (LDSST) is more sensitive but less specific than the standard dose test for the diagnosis of adrenal insufficiency, and there are concerns regarding the accuracy of dosing in the LDSST.
Objective: Perform a retrospective, observational study to review the outcomes of LDSSTs performed in a tertiary endocrine service from 2008 to 2014 (N = 335) and 2016 to 2020 (N = 160), and examine for relationships between cortisol measurements and indication for testing, age and sex.
Methods: LDSST were performed by endocrine nurses.
Context: Growth hormone insensitivity (GHI) in children is characterized by short stature, functional insulin-like growth factor (IGF)-I deficiency, and normal or elevated serum growth hormone (GH) concentrations. The clinical and genetic etiology of GHI is expanding.
Objective: We undertook genetic characterization of short stature patients referred with suspected GHI and features which overlapped with known GH-IGF-I axis defects.